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OVERVIEW

×îÐÂÉ«ÇéӰƬ Benefits      Valuable Product Differentiation
×îÐÂÉ«ÇéӰƬ Capabilities      Facilities

As the inventor of softgel rotary die process, ×îÐÂÉ«ÇéӰƬ continues to lead the softgel industry with cutting-edge drug delivery innovations. Our award-winning soft capsule technology platform, OptiShell® Technology, further advances RP Scherer Softgel technology by providing development solutions for challenging drug compounds contained within complex fill formulations.

OptiShell capsules utilize a patented shell derived from plant polysaccharides that are ideally suited for the encapsulation of higher melting point fill formulations. Soft capsules containing semi-solid matrices for modified release of poorly soluble and/or poorly permeable drug compounds are now an option, only at ×îÐÂÉ«ÇéӰƬ! For immediate release applications, OptiShell technology expands the range of compatible excipients available for developing lipid-based capsule formulations, providing more solutions for solving unique drug delivery challenges.

OptiShell technology and ×îÐÂÉ«ÇéӰƬ RP Scherer Softgels combined enable encapsulation of broadened range of lipid-based formulations.

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CATALENT BENEFITS

• Improves bioavailability for a greater number of poorly water-soluble and poorly permeable compounds
• Modified or extended release of compounds from softgels
• Solves complex development and formulation challenges beyond conventional softgel technology
• Patented shell composition can handle:
  • Encapsulation of  high temperature fill formulations (up to 70ËšC) for semi-solid and highly viscous fill formulations
  • Higher pH fill formulations
  • A wider range of compatible fill excipients for enhancing drug bioavailability and stability

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VALUABLE PRODUCT DIFFERENTIATION

• Proprietary technology and process with strong IP protection
• Better patient adherence – easy to swallow
• Gelatin-free products for expanded markets
• Elimination of  shell odor and a non-distinguishing taste

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CATALENT CAPABILITIES

We have a long track record of customizing successful programs involving our proprietary advanced technologies:

• Pre-formulation and feasibility studies
• Solubility screening of New Chemical Entities
• Softgel capsule fill formulation development
• Small-scale lab encapsulation for early stability data and final formulation selection
• Shell development
• Strong IP (intellectual property) positions including fill formulations for improved bioavailability
• Extensive technical support in softgel capsule product development
• Reliable supply from clinical phases to commercial manufacturing
• Contingency planning and quality assurance via our large global network

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FACILITIES

Our deep formulation expertise supported by a global infrastructure of cGMP, FDA, EMA and locally accredited softgel facilities will provide a catalyst to your success by tailoring a unique drug delivery solution to bring your product faster to market.